Is Canada ready for therapeutic vaccines?

Typhoid vaccines ready for implementation.

n engl j med 361;4 nejm.org july 23, 2009 403 is narrowly tailored to focus on smoking prevention in the nation’s young, will survive any such legal challenge. The long-term impact of the Family Smoking Prevention and Tobacco Control Act on the health of the public will depend critically on its implementation through strict regulations, rigorously enforced. FDA Commissioner Margaret Hamburg and...

Therapeutic vaccines for prostate cancer.

Prostate cancer is the most common, noncutaneous cancer for men in the U.S., leading to more than 30,000 deaths a year. Vaccines for prostate cancer, which for several years have been shown to generate immunologic responses, are beginning to show significant clinical promise. At present, numerous therapeutic options are being investigated, including autologous and allogeneic whole-tumor cell va...

Therapeutic vaccines for gastrointestinal cancers.

Despite progress in the management of gastrointestinal malignancies, these diseases remain devastating maladies. Conventional treatment with chemotherapy and radiation is still only partially effective and highly toxic. In the era of increasing knowledge of the molecular biology of tumors and the interaction between the tumor and immune system, the development of targeted agents, including canc...

Therapeutic vaccines for ovarian cancer.

While therapeutic vaccines for ovarian cancer represent only a small fraction of active clinical trials, growing interest in this area and the accumulated data supporting the use of vaccines in cancer treatment portend further expansion of trials incorporating these strategies. This review explores the rationale for the use of vaccines for the treatment of ovarian cancer. It examines vaccine pl...

vertical gastric plication: is it ready for prime-time?